Katerina Politi, PhD is an Associate Professor in the Departments of Pathology and Medicine (Section of Medical Oncology) at Yale University. She is an expert in cancer biology, and mouse modeling of lung cancer with a specific focus on EGFR mutations in lung cancer. She developed genetically engineered mouse models to study EGFR mutations in vivo and has been a leader in understanding mechanisms of acquired resistance to targeted therapies. In this regard, her laboratory studies the molecular mechanisms that underlie sensitivity and resistance to targeted therapies in lung cancer using genetically engineered mouse models, patient-derived models and direct analysis of patient specimens. Additionally, her laboratory also studies the role of lung cancer-associated genetic alterations in metastatic progression and cell signaling. Finally, her laboratory is investigating the role of the tumor microenvironment in lung cancer with special emphasis on understanding its contributions to tumorigenesis and response to therapy including new drugs that target the immune system.