The Loyal Goff Laboratory seeks to answer a fundamental biological question: How is the genome properly interpreted to coordinate the diversity of cell types observed during neuronal development? They focus on the acquisition of specific cellular identities in neuronal development and identification of the molecular determinants responsible for proper brain development. Using novel experimental approaches for the enrichment and purification of specific neuronal cell types and recent technological advances in single-cell RNA sequencing, they can discover and explore the cellular factors that contribute to neuronal cell fate decisions during mammalian brain development.