jose javier bravo-cordero headshot

J. Javier Bravo-Cordero, Ph.D.

Associate ProfessorIcahn School of Medicine at Mount Sinai

Dr. Bravo-Cordero is an Associate Professor at the Department of Medicine, Division of Hematology and Medical Oncology at Icahn School of Medicine at Mount Sinai and the Tisch Cancer Institute. He is also associate scientific director of the Microscopy and Advanced Bioimaging Core at Mount Sinai. Dr. Bravo-Cordero was trained as a cell biologist and molecular biologist. He earned his bachelor’s degree at Autonoma University of Madrid (Spain) and his PhD in Cancer Biology at the Spanish National Cancer Institute (CNIO, Spain) working on mechanisms of tumor cell invasion in 3D collagen matrices. He studied the role of MT1-MMP and Rab8GTPase in tumor cell invasion by using high-resolution imaging. During his postdoctoral training in the laboratories of Dr. John Condeelis and Dr. Hodgson at the Albert Einstein College of Medicine in New York, he extended his expertise in cancer metastasis by applying unique imaging technologies such as FRET microscopy and intravital imaging. He studied the spatiotemporal activation of RhoGTPases during invasion and matrix degradation by using a series of imaging tools (FRET biosensors) to visualize GTPase activation in real-time in living cells. He studied the role of the RhoGTPases RhoC, RhoA and Rac1 on extracellular matrix degradation mediated by a membrane degrading protrusion named invadopodia, formed by tumor cells. Dr. Bravo-Cordero's expertise ranges from microscopy (FRET microscopy, in vivo imaging) to cell biology and mouse models. The work at Bravo-Cordero Lab (“In vivo Imaging and Metastasis Lab”) is focus on understanding how tumor cells disseminate during metastasis. His lab is focus in understanding the biology of dormant cancer cells and how the interaction with the microenvironment, determinate the fate of disseminated cancer cells and the entrance and scape from dormancy at metastatic organs. To approach their scientific questions his lab develops multidisciplinary sets of imaging and cell biophysics tools (ranging from high-resolution intravital imaging, superresolution microscopy, FRET microscopy, light-sheet microscopy, quantitative imaging) in order to study the tumor cell phenotypes and the activation of signaling pathways in vivo. At the Microscopy and Advanced Bioimaging Core at Mount Sinai he also organizes a monthly seminar series that bring leaders in the microscopy field to Mount Sinai, a bi-annual 3-day symposium and hands-on workshop with Leica, and a Microscopy Course offered as part of the graduate school curriculum that teaches basic microscopy and physics and exposes students to novel applications with the ultimate goal of training the next generation of microscopists. His has published over 40 peer-reviewed publications, some of them in high impact journals such as Nature Cell Biology, Nature, Nature Cancer, Cell. He is also the recipient of a K22 Career Development Award, Career Catalyst Research Award from the Susan G. Komen, Young Investigator Award from the JJR foundation, the Irma-Hirschl Awards, the Schneider-Lesser Foundation Award and other independent grants from NIH.

Sessions
Jan 01 12:00 AM Speakers