At Massachusetts General Hospital, Brigham and Women’s Hospital, and Harvard Medical School, my efforts are concentrated in clinical and biomathematical research, and mentoring in clinical research. My areas of research are (i) the application of circadian and sleep research principles to normal and pathophysiologic states and (ii) mathematical analysis and modeling of human circadian, sleep, and neurobehavioral mood and performance rhythms. My teaching and mentoring work in patient-oriented research has been recognized with the awarding of a competitive renewal of my K24 grant support from NIH.

My clinical research focuses on the influences of circadian and sleep rhythms in normal and pathological states. Research projects have included studies of sleep and circadian rhythms in blind people, changes in sleep and performance in healthy aging, the effects of chronic sleep restriction on neurobehavioral performance and alertness and the effects of light and darkness on circadian rhythms. I have also done studies that combine outpatient and inpatient assessments of sleep and circadian rhythms.
I collaborate with investigators from other divisions and hospitals to apply the principles of circadian rhythms and sleep research to the study of human physiology and pathophysiology.

I am also Director of the Analytic and Modeling Unit (AMU) within the Division of Sleep and Circadian Disorders at BWH. The work in analysis, modeling and simulation of biologic systems has included systematic mathematical exploration of many aspects of sleep, circadian rhythms and performance. Members of the AMU have developed new analytic techniques, and modeled and simulated experimental results and predictions. The work is part of the cycle of experimental work- mathematical modeling and predictions- experimental work.