Ralda Nehme is a principal investigator in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, where she also directs the stem cell program. Her research is focused on investigating the genetic, cellular, and molecular mechanisms underlying neurodevelopmental and psychiatric diseases. The Nehme lab uses human stem cell based models, genome editing technologies, and image-based, electrophysiological, and genetics approaches to examine cellular phenotypes linked to human genetic variation. Through a large collaborative effort, they have established a key resource of human pluripotent stem cells and genetic data from hundreds of donors, aimed at expanding the scalability of experimental systems and understanding how specific genetic variants influence cellular phenotypes.