Ewelina Bolcun-Filas, Ph.D.
Associate ProfessorThe Jackson Laboratory
Ewelina Bolcun-Filas is an Associate Professor at The Jackson Laboratory in Bar Harbor, Maine. Her research aims to identify molecular mechanisms controlling development of healthy ovarian egg reserve, and how misregulation of these mechanisms can lead to infertility. Born in Poland, she received her M.Sc. in biology from Jagiellonian University in Krakow, Poland. She earned her Ph.D. from Georg-August-University in Gottingen, Germany. To pursue her interests in reproductive biology she joined MRC Human Genetics Unit in Edinburgh, Scotland as a postdoctoral fellow.
In 2008 she moved across the ocean to reunite with her family living in Connecticut and continued her research into genetic causes of infertility at Cornell University in Ithaca, NY. Her work identified an essential signaling pathway responsible for culling of abnormal oocytes and ensuring survival of only high quality eggs. She further demonstrated that the same mechanism eliminates immature eggs exposed to radiation; a common cancer therapy which can lead to premature ovarian failure and infertility in cancer survivors. Her discovery promises new approach for fertoprotective treatments for cancer patients. She joined The Jackson Laboratory in January 2015 where she continues her work investigating genetic causes of infertility and mechanisms of cancer therapy-induced ovarian toxicity. The goal of her research is to develop genetic risk prediction methods and new treatments for preservation of healthy ovarian function and fertility in female cancer survivors.