CD34+ Humanized NSG-FLT3-IL15 Mice

Appearance & Care

NSG-FLT3-IL15 Mouse - The Jackson Laboratory

While CD34+ hematopoietic stem cell humanized mice do have a human-like immune system on-board, it is not fully functional. These mice should still be handled very carefully and treated as an immuno-deficient strain. We are glad to offer the following resources to help you care for highly immuno-deficient strains like NSG™. Additionally, you should be sure to check with your institution regarding requirements for housing mice with engrafted human tissue.

Animal Health Reports

AX18 (Maximum)

Phenotype Information

Phenotype Information

hCD45+ Cells
CD34 humanized NSG-FLT3-IL15 - Phenotype Info - CD45 Engraftment
CD3+ T Cells
CD34 Humanized NSG-FLT3-IL15 - Phenotype Info - CD3+ T Cells

Figure 1. CD34 humanized NSG-F15 mice demonstrate stable engraftment of CD45 cells (left) and CD3+ T cells at similar levels as parental strains over 28-weeks. Depicted data is the average of 3 different CD34 donors over 28-week period.

Myeloid Cell Data

CD33+ Myeloid Cells
CD34 Humanized NSG-FLT3-IL15 - Myeloid Cell Data - CD33+ T Cells
CD33+ Myeloid Cells
CD34 Humanized NSG-FLT3-IL15 - Myeloid Cell Data - CD33+ Cells/ul

Figure 2. CD34 humanized NSG-F15 mice demonstrate relatively similar abundances of CD33+ myeloid cells as parental CD34 Humanized NSG-FLT3 mice in whole blood (left) and overall higher levels of CD33+ myeloid cells in whole blood as compared to parental strains (right). Depicted data is the average of 3 different CD34 donors over 28-week period.

Natural Killer Cell Data

Immature Natural Killer Cells
CD34 Humanized NSG-FLT3-IL15 - Immature NK Cell Data

Figure 3. CD34 humanized NSG-F15 mice demonstrate similar levels of immature NK cells as parental CD34 humanized NSG-FLT3 (top left), similar levels of mature natural killer cells as parental CD34 humanized NSG-IL15 (bottom left and bottom right). Depicted data is the average of 3 different CD34 donors over 28-week period.

Mature Natural Killer Cells
CD34 Humanized NSG-FLT3-IL15 - Immature NK Cellular Data
Mature Natural Killer Cells
CD34 Humanized NSG-FLT3-IL15 - NK Cell Data

B Cell Data

CD19+ B Cells
CD34 Humanized NSG-FLT3-IL15 - B Cell Data

Figure 4. CD34 humanized NSG-F15 mice demonstrate lower abundances of CD19+ B cells as compared to CD34 humanized NSG and NSG-FLT3 mice. Depicted data is the average of 3 different CD34 donors over 28-week period.

Dendritic Cells

Conventional Dendritic Cells
CD34 humanized NSG-FLT3-IL15 - Conventional Dendritic Cells
Plasmacytoid Dendritic Cells
CD34 Humanized NSG-FLT3-IL15 - Plasmacytoid Dendritic Cells

Figure 5. CD34 humanized NSG-F15 mice demonstrate similar abundances of conventional and plasmacytoid dendritic cells as parental CD34 humanized NSG-FLT3 mice. Depicted data is the average of 3 different CD34 donors over 28-week period.

References & Resources

FLT3-IL15 Naïve Strain Data Sheet
AACR 2024 Poster

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