Retinal degeneration 5 rd5
Retinal degeneration 5 (rd5)
rd5 was found in C57BL/6J-tub, now a subline of C57BL/6J wherein a mutation to tubby (tub) occurred in 1977. The retinal degeneration aspects of tub homozygotes have been presented as a mutant gene, rd5, but tub and rd5 may be the same gene.
The involvement of tub in obesity, retinal degeneration and hearing loss suggests it as a model for the Alstrom (OMIM 203800) or Bardet-Biedl (OMIM 209900) syndromes.
|
Gene |
Mouse Chromosome |
Human Chromosome |
Retinal ONL disappear by |
Strains |
|---|---|---|---|---|
| rd5(tub) | 7 | 11p15 | 8 | c57BL/6J-tub |