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Trem2 Models

MODEL JAX # TYPE DESCRIPTION NOMENCLATURE REFERENCE
Trem2 KO 27197 Knock-out Deletion of 175bp introduces a stop codon at amino acid 17. C57BL/6J-Trem2em2Adiuj/J
Trem2*R47H 27918 Knock-in Knock-in of R47H risk variant into mouse locus C57BL/6J-Trem2em1Adiuj/J PMID:37016304
Trem2*R47HHSS 33781 Knock-in Knock-in of R47H risk variant into mouse locus with humanized splice acceptor site B6.Cg-Trem2em4Adiuj/J
Trem2*R47HNSS 34036 Knock-in Knock-in of R47H risk variant into mouse locus with normalized splice acceptor site B6(SJL)-Trem2em1Aduci/J PMID:36803190
Trem2*Y38C 29725 Knock-in Knock-in of Y38C risk variant into mouse locus C57BL/6J-Trem2em3Adiuj/J PMID:33115519
hTREM2-KI 38103 Knock-in Knock-in of human coding sequence replacing corresponding mouse sequence C57BL/6J-Trem2em3(TREM2)Aduci/J
hTREM2-R47H_KI 37497 Knock-in Knock-in of human coding sequence with R47H risk variant replacing corresponding mouse sequence C57BL/6-Trem2em2(TREM2*R47H)Aduci/J
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