This MMTV-Cre Line D transgenic strain expresses Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B cells and T cells. Little background recombination was observed in the lung, kidney, liver and brain tissues (less than 10%). MMTV-Cre Line D is not reported to have any significant expression in oocytes. The donating investigator indicates that MMTV-Cre Line D may be suitable for use in applications where it is desirable to delete genes in the virgin and lactating mammary gland, skin, erythroid cells, and other secretory tissues.
 Of note, also available is MMTV-Cre Line A (Stock No. <a href="https://www.jax.org/strain/003551">003551</a>) that has some similarities, but also has expression in the female germline.

These MMTV-Cre/Line D mice express a transgene containing the MMTV LTR promoter directing expression of Cre recombinase. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B cells and T cells. MMTV-Cre Line D is not reported to have any significant expression in oocytes. Of note, also available is MMTV-Cre Line A (Stock No. <a href="https://www.jax.org/strain/003551">003551</a>) that has some similarities, but also has expression in the female germline.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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