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B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J

What Does This Nomenclature Mean?
Strain #:008169
RRID:IMSR_JAX:008169Info
Common Name: Tau P301S (PS19)

This strain ships with remnant UID MiniMax microchips implanted subcutaneously in the back. For more information on these RFID chips, including our FAQ, please visit our Mouse Identification page.

The PS19 mouse model harbors the T34 isoform of microtubule-associated protein tau with one N-terminal insert and four microtubule binding repeats (1N4R) encoding the human P301S mutation, all driven by the mouse prion protein promoter. These mice are useful in studying neurofibrillary tangles, neurodegenerative tauopathy and Alzheimer's disease.

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