The Fxnflox/null::PV-Cre genotype is compound heterozygous at the frataxin locus (floxed exon 2 and global KO on respective homologous chromosomes) and heterozygous for the PV-Cre knockin allele. Due to early-onset ataxia, Fxnflox/null::PV-Cre are distributed at 4-7 weeks of age. In addition, we distribute the phenotypically-normal parental lines: i. Stock No. 028520: C57BL/6J-congenic Fxnem2Lutzy (homozygous for floxed exon 2) ii. Stock No. 030218: C57BL/6-congenic Pvalbtm1(cre)Arbr Fxnem2.1Lutzy (homozygous for PV-Cre knockin and heterozygous for frataxin global KO). These breeders produce the affected Fxnflox/null::PV-Cre genotype at a 1/2 frequency.
Our pre-clinical services offer scientific expertise, numerous in-life and end point measurements, phenotyping capabilities and flexible, customizable study design for compound evaluations using Friedreich's Ataxia mouse models. See our full service platform." name="jax.publicweb.shortDescription" data-next-head="">029721 - Fxn[flox/null]::PV-Cre Strain Details
Common Name: Fxnflox/null::PV-Cre | Also Known As: B6 Pvalb-IRES-Cre;Fxnflox/null
Fxnflox/null::PV-Cre mice have a Cre-conditional frataxin allele, global knockout frataxin allele and parvalbumin neuron-specific Cre recombinase knockin allele - useful to study Friedreich's Ataxia.
The Fxnflox/null::PV-Cre genotype is compound heterozygous at the frataxin locus (floxed exon 2 and global KO on respective homologous chromosomes) and heterozygous for the PV-Cre knockin allele. Due to early-onset ataxia, Fxnflox/null::PV-Cre are distributed at 4-7 weeks of age. In addition, we distribute the phenotypically-normal parental lines: i. Stock No. 028520: C57BL/6J-congenic Fxnem2Lutzy (homozygous for floxed exon 2) ii. Stock No. 030218: C57BL/6-congenic Pvalbtm1(cre)Arbr Fxnem2.1Lutzy (homozygous for PV-Cre knockin and heterozygous for frataxin global KO). These breeders produce the affected Fxnflox/null::PV-Cre genotype at a 1/2 frequency.
Our pre-clinical services offer scientific expertise, numerous in-life and end point measurements, phenotyping capabilities and flexible, customizable study design for compound evaluations using Friedreich's Ataxia mouse models. See our full service platform.
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