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B6.Cg-Apoetm1.1(APOE*4)Adiuj Clasp2em1Adiuj Trem2em1Adiuj/J

What Does This Nomenclature Mean?
Strain #:031944
RRID:IMSR_JAX:031944Info
Common Name: Clasp2*L163P/APOE4/Trem2*R47H
This triple mutant strain carries a humanized ApoE knock-in mutation (sequence coding for isoform E4), a CRISPR/cas9-generated L163P point mutation of the Clasp2 (CLIP associating protein 2) gene and a CRISPR/cas9-generated R47H point mutation of the Trem2 gene. These mice may be suitable for use in studies related to Alzheimer's disease, lipoproteins, arteriosclerosis, and coronary heart disease.
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