In Vivo Pharmacology

We specialize in the production of innovative oncology research models including PDX models and compound evaluation using PDX or cell line xenograft models, and efficacy testing of cancer immunotherapeutics.

Our preclinical testing facility specializes in the production of cutting-edge immunological research models including humanized CD34⁺and PBMC mice and compound evaluation of standardized preclinical models of autoimmune and inflammatory diseases.

We offer a diverse set of efficacy – testing capabilities and compound evaluation in the areas of muscular dystrophy and neurodegeneration.

Over 300 patient-derived xenograft (PDX) tumors are available for engrafting into immunocompromised NSG™ mice for shipment to your facility or use in JAX-directed preclinical efficacy studies.

Humanized mouse models are powerful tools for studying cancer, inflammatory and infectious disease, and hematopoiesis. We provide fast access to study-ready cohorts.

We evaluate the pharmacokinetics, bioavailability and efficacy of therapeutic monoclonal antibodies in vivo, using unique JAX-generated FcRn-humanized models.