How to cite this resource
Please reference the Mouse Resource for Craniofacial Research in citations acknowledging use of the resource.
This resource grew out of two separate NIH programs. The FaceBase Consortium, a five-year initiative to construct the middle region of the human face and precisely define the genetics underlying common developmental disorders of the human face, provided support from 2009-2014 (DE020052). Separately, development of spontaneous mutant models of craniofacial disorders began under an R01 (EY015073) between 2009-2013. Combined, these two programs formed the foundation for a diverse resource of models for craniofacial research.
Current support for the resource comes from The Jackson Laboratory and the sale of mice.
-
ArticleAugust 14, 2024From mice to medicine - six questions with Nadia Rosenthal
How working with genetically diverse could revolutionize our understanding of human disease and treatment. -
ArticleJuly 24, 2024Researchers are closing in on a mouse model for late-onset Alzheimer’s research
Mice don’t get Alzheimer’s—and while that’s good news for mice, it’s a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that’s genetically susceptible to late-onset Alzheimer’s, with potentially transformative implications for dementia research. -
Featured ArticleJuly 09, 2024What is genetic biomarker testing?
Genetic testing is a powerful tool in the fight against cancer, playing a crucial role in both prevention and personalized treatment. But what exactly are the different types of genetic tests, and how do they help? -
Research HighlightJune 05, 2024Revealing potential therapy targets for cancer
Reenergizing exhausted T cells, with help from a rare immune cell known as a basophil, can kickstart the immune system into fighting cancer.
-
ArticleAugust 14, 2024JAX researchers call for genetically diverse models to drive innovation in drug discovery
Diverse mouse models show promise in how we understand and treat diseases, offering a significant improvement over standardized but limited mouse and cellular models. -
Research HighlightJuly 10, 2024Charles Lee continues to sequence repetitive areas of the genome
Charles Lee co-leads the Human Genome Structural Variation Consortium and is uncovering structural variations in the human genome. -
Blog PostJune 27, 20245 things: research tools and methods that may be medical game changers
Explore five research tools and methods that didn't exist ten years ago that could be medical game changers. -
Featured ArticleApril 23, 2024Dan Cortes: gearing up for discovery
Dan Cortes multifaceted journey has led him to pioneering stem cell research within the Pera lab, where he explores the intricate genetic landscape underlying neurological diseases and disorders.
Selected publications
Curtain M, Heffner CS, Maddox DM, Gudis P, Donahue LR, Murray SA. 2015. A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice. Mamm Genome. 2015 Apr;26(3-4):173-80. doi: 10.1007/s00335-015-9557-z. Epub 2015 Feb 12.PMID: 25673119
Murray SA, Eppig JT, Smedley D, Simpson EM, Rosenthal N. 2012. Beyond knockouts: cre resources for conditional mutagenesis. Mamm Genome 23(9-10):587-599. PMCID: PMC3655717
Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LRD, Fraser SE, Iwata J, Marazita ML, Murray JC, Murray SA, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. 2011. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol 355(2):175-82. PMCID: PMC3440302
Murray SA. 2011. Mouse resources for craniofacial research. Genesis 49(4):190-9. PMCID: PMC3610317
Fairfield H et al. 2011. Mutation discovery in mice by whole exome sequencing. Genome Biol. 12(9):R86. PMCID: PMC3308049.
Keane TM et al. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477:289-294. PMCID: PMC3276836.
Odgren PR, Pratt CH, Mackay CA, Mason-Savas A , Curtain M, Shopland L, Ichicki T, Sundberg JP , Donahue LR. 2010. Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies. PLoS One Apr1:5(4):e9959.PMCID:2848607.