LIMITED USE LABEL LICENSE: RESEARCH USE ONLY

This animal model (“Model”) is the subject of a license granted to The Jackson Laboratory from Caribou Biosciences, Inc., and this Model is transferred to the end-user purchaser or other end user (collectively, “Recipient”) subject to this “Limited Use Label License” conveying to the Recipient a limited, non-transferable right to use (i) this Model, (ii) any and all progeny thereof generated by the Recipient, and (iii) any and all biological material extracted or derived from this Model or its progeny (collectively, (i), (ii), and (iii) are referred to as “Material”) only to perform internal research for the sole benefit of the Recipient. 

The Recipient shall not sell or otherwise transfer the Material to a third party, other than a third party under a contractual obligation to perform research for the sole benefit of the Recipient or a third party that is a nonprofit performing collaborative research with the Recipient. The Recipient shall not use the Material for any Excluded Use. “Excluded Use” means any and all: (a) commercial activity, including but not limited to bioproduction or related bioproduction quality control; (b) use to provide a service, information, or data to a third party; (c) use as a product for therapeutic, diagnostic, or prophylactic purposes; (d) sale, resale, leasing, or licensing, whether or not for research purposes; (e) activity in an agricultural field trial or any activity directed toward the submission of data to the U.S. Department of Agriculture or any other agriculture regulatory agency; (f) high throughput screening drug discovery purposes (i.e., the screening of more than 10,000 experiments per day) as well as scale-up production activities for commercialization; (g) modification of human germline, including editing of human embryo genomes or reproductive cells; (h) self-editing; and/or (i) stimulation of biased inheritance of a particular gene or trait or set of genes or traits (“gene drive”).  For the avoidance of doubt, the Recipient may use the Material in its internal therapeutic research pipeline, including for example, drug safety and efficacy studies, target identification, anti-body evaluation, and any other pre-clinical testing and evaluation that is not an Excluded Use.

It is the Recipient’s responsibility to use the Material in accordance with all applicable laws and regulations.

For information on obtaining additional rights, including commercial rights, please contact licensing@cariboubio.com or Caribou Biosciences, Inc., 2929 7^th Street, Suite 105, Berkeley, CA 94710 USA, Attn: Licensing.