Preclinical Oncology Platforms

We develop innovative preclinical models and services that enable informed decision making and compound evaluation. De-risk drug development and move your therapeutic into the clinic faster.

JAX Preclinical Services offers the most translational and predictive efficacy, pharmacokinetics (PK) and safety testing for therapeutics such as monoclonal antibodies, bispecifics, CAR-T, antibody-drug conjugates, and combination therapies.

By combining genetically defined tumors with innovative humanized mouse models, JAX enables the validation of therapeutic candidates in an array of in vivo platforms that better recapitulate the human condition.

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Onco-Hu HuPK™ (FcRn)CRS Safety Studies PDX Models Syngeneic Studies Immuno-oncology

Oncology Models And Study Capabilities

Be confident in your lead selection and dosing decisions with predictive and translationally relevant data delivered by JAX Preclinical Oncology Services.

PDX Library

Confirm biomarkers with slides and FFPE samples
RNASeq data available for many models
Comprehensive efficacy studies available using your therapeutic
Verified growth characteristics
Low passage tumor models

Onco-Hu Studies

Most translational model for immunotherapies
Test therapeutic efficacy in the presence of human immune cells and human tumors
Compare multiple CD34+ donors or multiple tumor profiles

HuPK For Antibody Therapeutics

Accurately evaluates pharmacokinetics of monoclonal antibodies, bispecifics, ADCs, and albumin conjugates
Determine first-in-human dosing
Reduce dependency on non-human primates

CRS Safety Studies

Test clinically-relevant cytokines in the presence or absence of tumor
Compare multiple PBMC donors or multiple tumor models
Measure downstream toxicities
In-life measures and comprehensive histopathology available

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NSG Portfolio Immune Humanized Mice Blood and Tissue Collection JAX Mouse Search Cell Line Efficacy

Learn More About The
Jackson Laboratory's Oncology
Capabilities

Watch our on-demand webinar on humanized platforms for mAb, bispecific, and CAR-T therapeutics to see how JAX's models and services can produce the most predictive and translationally-relevant data for your next IND.

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