Breakthrough Lab

Human iPS Cells

In partnership with the iPSC Neurodegenerative Disease Initiative, a project from the Center for Alzheimer’s and Related Dementias (NIH), and with support from the Chan Zuckerberg Initiative, and Aligning Science Across Parkinson's (ASAP), The Jackson Laboratory now offers a catalog of human induced pluripotent stem cells (iPSCs) for Alzheimer’s and Related Dementias (ADRDs), ALS, and other neurodegenerative disorders.

Cytokine Release Syndrome (CRS) Studies

The Cytokine Release Evaluation Study will give you the kind of donor-to-donor variability you’d expect find in the clinic, as well as greater sensitivity and specificity than with the alternative in vitro and non-primate options.

Myotonic Dystrophy (DM)

MASH Models

JAX has the most comprehensive portfolio of MASH (formerly called non-alcoholic steatohepatitis, or NASH) mouse models to support your preclinical research needs. Leverage both traditional and novel MASH models to test your unique research questions, and gain confidence in your study results by utilizing the models that are right for you.

The ABC’s of CAR T Cell Therapies

Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor T-cells, promoting their own survival. Immunotherapeutic approaches, by design, overcome these tumor mediated inhibitory mechanisms, allowing the patient’s immune system to thwart the invading tumor.