Immunodeficient & Nude Mouse Models
Immunodeficient mice are invaluable tools in biomedical research, offering utility in studying various aspects of immunology, oncology, infectious disease, and cell and tissue transplantation. Their limited ability to mount an immune response permits the transplantation of mouse or human cells and tissues, enabling the development of novel therapies and vaccines through in vivo testing of potential therapeutics.
Immunodeficient mouse models also facilitate the study of diseases such as type 1 diabetes and autoimmune syndromes by allowing investigation of the mechanisms underlying immune system dysregulation. These mice play a crucial role in advancing our understanding of the immune system and in the development of innovative medical treatments.
The Jackson Laboratory offers a variety of immunodeficient mouse models, ranging from slightly immunocompromised (NU/J and J:NU) to extremely immunodeficient (NOD scid gamma and NOD Rag gamma), enabling a range of experimental procedures from murine cancer cell line engraftment to immune-humanization with CD34+ hematopoietic stem cells and PBMCs.
