While CD34+ hematopoietic stem cell humanized mice do have a human-like immune system on-board, it is not fully functional. These mice should still be handled very carefully and treated as an immuno-deficient strain. We are glad to offer the following resources to help you care for highly immuno-deficient strains like NSG™. Additionally, you should be sure to check with your institution regarding requirements for housing mice with engrafted human tissue.
RB03 (Maximum) |
Figure 1. CD34 Humanized S-15 mice demonstrate engraftment of CD45 cells (left) and differentiation of mature natural killer cells (right) as compared to parental strains following transplantation.
Figure 2. CD34 Humanized S-15 mice demonstrate presence of CD33+ myeloid progenitor cells (left) and CD14+ monocytes (right) at 8 weeks at similar levels as to CD34 humanized NSG-SGM3 parental strains.
Figure 3. CD34 Humanized S-15 mice demonstrate presence of CD4+, CD8+, and T regulatory cells in a similar manner to its CD34 humanized SGM3 parental strain.
Figure 4. CD34 Humanized S-15 mice demonstrate successful transplantation of patient-derived PS4050 melanoma (left) and cell-line derived MDA-MB-231 breast cancer cells (right).
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