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JAX Frontend Platform

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CD34+ Humanized Mice

Human CD34+ hematopoietic stem cell-engrafted NSG™ or NSG™ variant mice (hu-CD34) develop multi-lineage human immune cells, and are a validated platform for immunology or immuno-oncology efficacy studies, and infectious disease research. Our inventory has CD34+ mice available for immediate shipment to your facility or efficacy study enrollment at ours.

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Humanized CD34+ mice are supreme in vivo models to study immunology, infectious diseases, and more. For example, NSG™engrafted models offer the longest research span, over 12 months with a functional human immune system displaying T-cell dependent inflammatory responses with no donor cell immune reactivity towards the host.

Hu-CD34+ mice produced by injecting CD34+ hematopoietic stem cells (hu-CD34) demonstrate robust multi-lineage engraftment of human immune cell populations including very good T cell maturation and function for long-term studies. JAX has been the pioneer of developing cutting-edge immunodeficient strains such as the NSG™ models and its variants to enable powerful research.

Key features:

  • Human CD34+ cells stably engraft the bone marrow.
  • Engraftment is stable for over one year without graft-versus-host disease.
  • CD4+ and CD8+ T cells are present in circulation and other tissues (Shultz et al. 2005).
  • With the hu-IL15, you can test the efficacy of NK-cell mediated therapeutics, including ADCC
  • Hu-CD34 NSG models are ideally suited for testing therapeutics with antigen-independent T cell MOA.
  • CD34+ hu-NSG-SGM3 are best for therapeutics with T cell and myeloid cell dependent MOA, including those that target AML

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Looking for blogs, on-demand videos and livestreams that JAX about Humanized mice? Visit our humanized mouse content hub for all the latest JAX humanized mouse resources.

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