Human peripheral blood mononuclear cell-engrafted NSG™ and NSG™-SGM3 mice are perfect for short-term experiments requiring mature T cells, including HIV infection, immuno-oncology, and graft-versus-host disease studies.
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Human peripheral blood mononuclear cell-engrafted NSG™ and NSG™-SGM3 mice are perfect for short-term experiments requiring mature T cells, including HIV infection, immuno-oncology, and graft-versus-host disease studies.
Humanized PBMC mice are used as in vivo models to study and evaluate compounds for infectious diseases and graft rejection research. This model has the fastest engraftment rate using adult peripheral blood mononuclear cells and enables short-term studies requiring a strong effector and memory T cell function. Created with adult peripheral blood mononuclear cells, engrafting quickly and enabling short-term studies requiring mature human T cells.
hu-PBMC-NSG MHC I/II Double Knockout
Humanized PBMC-NSG MHC I/II Double Knockout mouse model has a significantly decreased xeno-GvHD relative to the PBMC humanized NSG mouse model, making it more suitable for immuno-oncology studies. This model is available humanized with pre-characterized PBMC donors for human immune cell engraftment kinetics. May be best used with cell lines or PDX models with reliable growth (PMID30383447)
| Model | hu-PBMC-NSG™ (745557) | hu-PBMC-NSG MHC I/II Double Knockout (742516) |
|---|---|---|
| Base Strain | NSG™ (005557) | NSG-(KbDb)null(IA)null (025216) |
| Human Cytokine Expression | N/A | N/A |
| Benefits |
|
|
| Lifespan | Short-term <3 month | >75-100d post-engraftment (Donor and Irradiation Dependent) |
| Immune Development | T cells (HLA-restricted CD4 and CD8), Natural Killer cells | Predominantly CD3+ T cells, with some NK cells |
| Availability | Readily Available | Readily Available |
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