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JAX Frontend Platform

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Autoimmune and Inflammatory Diseases

The Jackson Laboratory has developed and validated numerous autoimmune in vivo models to interrogate therapeutic candidates in a relevant and translational manner. These platforms and readouts can help you make informed decisions about which candidates to move forward towards IND.

JAX, with decades of experience standardizing mouse husbandry practices, has a deep understanding of immunological drivers of autoimmune disease progression.

JAX In Vivo Preclinical Efficacy Services delivers robust and reproducible data that enables confident preclinical go/no-go decisions, including:

  • Flexible study designs tailored to client requirements
  • Studies that are benchmarked against clinically approved Standard-of-Care therapies
  • Clinical Biomarker & Immunology-based readouts to understand candidates’ MOA
Lupus Models

Established and emerging models are available to understand the origins and treatment of the most common form of lupus, systemic lupus erythematosus (SLE)

Type 1 Diabetes Models

Pancreatic dysfunction underlies type 1 diabetes in mice including the commonly used autoimmune NOD/ShiLtJ model

Inflammatory Bowel Disease Models

Aberrant immune responses contribute to human inflammatory bowel disease as well as the mouse strains used to study colitis, Crohn’s disease, and other conditions

Leading the search for tomorrow's cures

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