Comparison of Widely Used JAX Mice for
Type 2 Diabetes and Obesity
This table compares the major type 2 diabetes and obesity phenotypes among humans and key models. Clicking on a model takes you to information detailing major phenotypes and important references.
Diabetes Phenotypes
|
Humans and Mouse Models (Stock number) |
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|---|---|---|---|---|---|---|---|---|---|---|---|
|
Phenotypes |
Humans |
BKS.Cg-Dock7m +/+ Leprdb/J |
C57BL/6J DIO |
TALLYHO/JngJ |
KK.Cg-Ay/J |
NEW! |
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| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced | Spontaneous | Spontaneous | Spontaneous | ||||
| Genetics | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic | ||||
| Onset | Mature (progressive) |
Young | Young | Mature | Mature | Mature | Mature | ||||
| Sex | M, F | M, F | M, F | M | M | M, F | M | ||||
| Hyperinsulinemia | Moderate | Severe | Moderate (transient) | Mild | Yes | Severe | Yes | ||||
| Glucose intolerance | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Hyperglycemia | Yes | Moderate (transient) |
Severe | Mild / Moderate | Yes | Yes | Moderate | ||||
| Islet atrophy | Variable | No (hyperplasia only) |
Yes | No | Yes (late onset) | Hypertrophy | Unknown | ||||
| Impaired wound healing | Yes | Yes | Yes | Yes | Unknown | Unknown | Unknown | ||||
| Nephropathy | Yes | No | Yes (mild) | No | Unknown | Yes | Unknown | ||||
Obesity Phenotypes
|
Humans and Mouse Models (Stock number) |
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|---|---|---|---|---|---|---|---|---|---|---|---|
|
Phenotypes |
Humans |
B6.Cg-Lepob/J B6.BKS(D)-Leprdb/J (000697) |
BKS.Cg-Dock7m +/+ Leprdb/J |
C57BL/6J DIO |
TALLYHO/JngJ |
KK.Cg-Ay/J |
NEW! |
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| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet- induced |
Spontaneous | Spontaneous | Spontaneous | ||||
| Genetics | Polygenic | Monogenic | Monogenic | Polygenic | Polygenic | Monogenic | Polygenic | ||||
| Onset | Variable | Young | Young | Mature | Juvenile | Mature | Young | ||||
| Sex | M, F | M, F | M, F | M | M, F | M, F | M | ||||
| Degree | Moderate | Severe | Severe | Severe | Moderate | Moderate | Moderate | ||||
| Hypertriglyceridemia | Yes | Yes | Yes | Mild | Yes | Yes | Yes | ||||
| Leptin/leptin receptor axis | Normal | Disrupted | Disrupted | Normal | Normal | Normal | Intact | ||||
| Hyperphagia | No | Yes | Yes | Mild | No | Yes | No | ||||
| Hypercorticism | No | Yes | Yes | No | Unknown | No | Unknown | ||||
| Thermoregulatory defects | No | Yes | Yes | Unknown | No | Unknown | No | ||||
| Liver steatosis | Variable | Severe | Severe | Unknown | Moderate | Moderate | Diet-induced | ||||