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Phenotype Information for 004456

NONcNZO10/LtJ

NONcNZO10/LtJ (also known as RCS-10) males develop maturity-onset diabetes without the extreme weight gain characteristic of other models. When fed a moderately high fat diet (LabDiet 5K20; 11% fat, w/w), NONcNZO10/LtJ males develop polygenic diabetes that includes

  • Modest weight gain, unlike ob/ob or db/db mice (Figure 1)
  • Non-fasting hyperglycemia that develops with age, in contrast to db/db mice with juvenile onset (Figure 2)
  • Glucose intolerance by 16 weeks of age (Figure 3)
  • Increasing abundance of glycated hemoglobin (% HbA1c), a stable marker for blood glucose levels (Figure 4)

Males are maintained on the 11% fat diet to maximize the metabolic phenotypes. If males are fed a lower-fat diet (4% w/w), they have significantly lower blood glucose levels, and they are more glucose-tolerant. NONcNZO10/LtJ females do not develop diabetes on either diet (JAX® NOTES Issue 497, Spring 2005).

Blood glucose measurements were obtained using a OneTouch® Ultra hand-held glucometer. For the glucose tolerance tests, mice were fasted 14-16 hours, and glucose was administered by oral gavage at 2g/kg body weight. Blood glucose was measured in 30 min intervals.

Figure 1. Modest weight gain of NONcNZO10/LtJ Mice

Figure 1. Modest weight gain of NONcNZO10/LtJ mice. Weekly body weights of NONcNZO10/LtJ males maintained on an 11% fat diet. Data represent mean values and standard deviations of 20 mice. As a reference, the mean body weights from BKS db/db mice (BKS.Cg-Dock7m +/+ Leprdb/J, Stock No. (000642)) are included from a separate study.


Figure 2. Non-fasting hyperglycemia increases with age

Figure 2. Non-fasting hyperglycemia increases with age. Weekly non-fasting blood glucose values from NONcNZO10/LtJ males maintained on an 11% fat diet. Data points represent mean values and standard deviations of 20 mice. As a reference, mean blood glucose values of BKS db/db mice (BKS.Cg-Dock7m +/+ Leprdb/J, Stock No. (000642)) are included from a separate study.


Figure 3. Glucose intolerance by 16 weeks of age

Figure 3. Glucose intolerance by 16 weeks of age. Oral glucose tolerance test of NONcNZO10/LtJ males on an 11% fat diet. Data points represent mean values and standard deviations of 10 mice.


Figure 4. Glycated hemoglobin increases with age

Figure 4. Glycated hemoglobin increases with age. The percentage of glycated hemoglobin (% HbA1c) at different ages, reported in International Federation of Clinical Chemistry (IFCC) units. Values represent means and standard deviations of 10 mice per age.

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