TALLYHO/JngJ
TALLYHO/JngJ males develop diabetes when maintained on standard mouse chow (6% fat, w/w). Features of this emerging polygenic model of type 2 diabetes include:
- Diabetes without the severe weight gain of db/db or ob/ob mutant mice (Figure 1)
- Non-fasting hyperglycemia (Figure 2)
- Glucose intolerance by 8 weeks (Figure 3). Similar results were obtained at 16 and 24 weeks.
- Glycated hemoglobin (% HbA1c), a stable marker for blood glucose levels, that increases with age (Figure 4)
Blood glucose measurements were obtained using a OneTouch® Ultra hand-held glucometer. For the glucose tolerance tests, mice were fasted 14-16 hours and glucose was administered by oral gavage at 2g/kg body weight. Blood glucose was measured in 30 min intervals.
![Figure 1. Modest weight gain of TALLYHO/JngJ mice](https://www.jax.org/-/media/jaxweb/images/jax-mice-and-services/graphics/005314_figure1.jpg?rev=2c02d3d0e3684cc2b9ddca36db1dce82&hash=ECD9C2B0E893B4D62917FF2CB2C0A66E)
Figure 1. Modest weight gain of TALLYHO/JngJ mice. Biweekly body weights of TALLYHO/JngJ males. Data represent mean values and standard deviations of 20 mice. As a reference, the mean body weights from BKS db/db mice (BKS.Cg-Dock7m +/+ Leprdb/J, Stock No. 000642) are included from a separate study.
![Figure 2. Elevated non-fasting blood glucose in TALLYHO/JngJ mice](https://www.jax.org/-/media/jaxweb/images/jax-mice-and-services/graphics/005314_figure2.jpg?rev=dd64901a215143b99b5cfa661a5209e7&hash=3DD14EC578EA678FF5E6CB0D98887246)
Figure 2. Elevated non-fasting blood glucose in TALLYHO/JngJ mice. Biweekly non-fasting blood glucose values of male TALLYHO/JngJ mice. Data represent mean values and standard deviations of 20 mice. As a reference, mean blood glucose values of BKS db/db mice (BKS.Cg-Dock7m +/+ Leprdb/J, Stock No. 000642) are included from a separate survey.
![Figure 3. Glucose intolerance by 8 weeks of age](https://www.jax.org/-/media/jaxweb/images/jax-mice-and-services/graphics/005314_figure3.jpg?rev=ba629c39d5204e3c835c30b354967f8d&hash=772F7FE183789D70942D95C1E9DD39CE)
Figure 3. Glucose intolerance by 8 weeks of age. Oral glucose tolerance test (OGTT) of 8 week old TALLYHO/JngJ males. Data represent mean values and standard deviations of 10 mice.
![Figure 4. Glycated hemoglobin increases with age](https://www.jax.org/-/media/jaxweb/images/jax-mice-and-services/graphics/005314_figure4.jpg?rev=2b06805b38bd4cec97318b2e6c30c089&hash=EA0181EF30E557A2743392FA7D886F3B)
Figure 4. Glycated hemoglobin increases with age. The percentage of glycated hemoglobin (% HbA1c) at different ages, reported in International Federation of Clinical Chemistry (IFCC) units. Values represent means and standard deviations of 10 mice per age.