Diabetes Onset in NOD/ShiLtJ
Stock Number 001976
![Diabetes Onset in NOD/ShiLtJ (001976)](https://www.jax.org/-/media/jaxweb/images/jax-mice-and-services/graphics/2022/1976_diabetes_curve.png?rev=c467ece2398a4a3593d6370501284250&hash=03DC3C1A1D69C5E2C32FC8A3A9BEF33C)
Diabetes onset was monitored weekly between the ages of 3 and 30 weeks in 120 female and 80 male NOD/ShiLtJ from the Bar Harbor and Sacramento facilities. Mice were fed a 6% fat diet (LabDiet 5K52 formulation), ad libitum. Diabetes was defined by a non-fasting blood glucose level exceeding 250 mg/dL. Blood was sampled in the morning from the submental route and analyzed using a OneTouch Ultra handheld glucometer that was validated using a control solution on each measurement day.
Median female onset was 18 weeks. Data were combined from two independent studies, one conducted in a Standard Barrier and the other in a Maximum Barrier. The Kaplan-Meier diabetes onset curves did not differ significantly between the individual studies. Diabetes onset curves were not significantly different from a similar study conducted in 2017. Body weights from this study are also available.