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The Ren Lab

To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse

Our Research Focus

The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.

Full Scientific Report

The Jackson Laboratory Cancer Center

Principal Investigator

Guangwen Ren, Ph.D.

Location

Bar Harbor, ME

Contact

207-288-6783

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Topics

Management of Genetic Risk, In Vivo Pharmacology & Preclinical Research Services, Cancer Cell Line Xenograft Efficacy Studies, PDX Efficacy Services, PDX-Seq, Patient-Derived Acute Myeloid Leukemia (AML) Models, Patient-Derived Xenograft (PDX) Models, PDX Live™: Efficacy Studies on Demand, Onco-Hu® Mouse Models, Immuno-oncology, Preclinical Oncology Platforms​, Family History Pedigree Tool, Colorectal Cancer Resources, The JAX Cancer Center, Breeding Services, Comparing Genetic Tests, Ethical Issues in Genetics, Clinical Education Resources, Hereditary Cancer Resources, Breast Cancer Resources, JAX® Mice & Services, Immune Humanized Mouse Models, Oncology Services Form, PDX Live™ Tumor Interest Form, Featured JAX® Mice for Cancer Research, Online Resources for Cancer Research, Solutions by Therapeutic Area, NSG™ Variants Portfolio, Find Lab Mice, Most Popular JAX Mice Strains, Minute to Understanding: What are telomeres?, Say goodbye to one-size-fits-all cancer treatments, Cancer Research Training and Education Coordination, JAX Cancer Center Membership Resources, Hereditary Breast and Ovarian Cancer Syndrome, Communicating with Family, Genetically Related Cancers, Case: Variant of Uncertain Significance, Case: Identify patients for germline testing, Why JAX® Mice?, Cancer, Membership, JAX Cancer Research News, JAX Cancer Center Yearly Highlights, Genetic Testing Results Interpretation Tool, Lynch Syndrome Factsheet, Familial Adenomatous Polyposis, Components of a Cancer Genetic Counseling Session, Communicating Genetic Risk, Three things to know about direct-to-consumer breast cancer genetic testing, Hereditary Cancer Management Guidelines, Cancer Genetic Risk Assessment, Customer Support, JAX Center for Aging Research, Minute to Understanding: What is epigenetics?, Aging Service Project Quote, Aged C57BL/6J Mice, CD34+ Humanized NSG-FLT3 Mice, Minute to Understanding: Lifespan vs. healthspan, Could 100 be the new 50?, Frequently Asked NSG™ Questions, Housing and Breeding Considerations for NSG™ Mice, Flow Cytometry Characterization Data for Immunodeficient JAX Strains, NSG™ Variants by Research Area, Biology of Beta Cell Consortium, Imiquimod-Induced Psoriasis Efficacy Studies, Lupus Efficacy Studies, Immunology Services, Genome Scanning Service, Fine-tuning our immune response so drugs work better when time means everything., Immune Disorders, Mouse Mutant Resource, Mouse Peroxisome Research Resource

Lab Staff

Leading the search for tomorrow's cures

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