The Rosenthal Lab
Investigating the role of growth factors, stem cells and the immune system in cardiovascular and skeletal muscle disease and regeneration.
Principal Investigator
Location
Topics
The Rosenthal Lab uses mammalian genetics to explore the the role of growth factors, stem cells and the immune system in the development and regeneration of heart and skeletal muscle. Our recent research uses mouse genetic diversity panels to investigate the role of aging, cellular interactions and the immune system in cardiovascular disease and repair. Genetic mapping reveals distinct spectra of cell composition and response in regenerative scenarios, demonstrating how background genetics can either facilitate or prevent tissue repair. In our infectious disease research, we have recently created more precise mouse models for SARS-CoV-2, using them to examine the role of host genetics in susceptibility and disease course. This work was published in Nature Communications.
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Media ReleaseDecember 05, 2024CAST mouse model: A crucial tool for future Covid-19 outbreaks
Mice with a genetically pure background are susceptible to severe SARS-CoV-2 infection -
Media ReleaseSeptember 27, 2024The Jackson Laboratory celebrates heart education and research with the completion of a new course that empowers cardiology clinicians
Through interactive, case-based lessons, the series empowers cardiology clinicians to move beyond a one-size-fits-all approach, enabling them to adopt more targeted management strategies for their patients. -
ArticleAugust 14, 2024JAX researchers call for genetically diverse models to drive innovation in drug discovery
Diverse mouse models show promise in how we understand and treat diseases, offering a significant improvement over standardized but limited mouse and cellular models. -
Media ReleaseJuly 24, 2024New analysis - targeted Alzheimer’s research and drug discovery
Researchers at The Jackson Laboratory offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer’s Disease in advance of the Alzheimer's Association International Conference, July 28
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Media ReleaseOctober 09, 2024Study probes how eating less can extend lifespan
Researchers at The Jackson Laboratory conduct pivotal study into aging and lifespan to uncover new details about how diets might make people live longer — but also their negative side effects -
ArticleAugust 14, 2024From mice to medicine - six questions with Nadia Rosenthal
How working with genetically diverse could revolutionize our understanding of human disease and treatment. -
ArticleJuly 29, 2024MODEL-AD drives progress for Alzheimer’s research
The July issue of Alzheimer’s & Dementia spotlights progress by MODEL-AD and its work to create better models for Alzheimer’s disease research and catalyze progress in the field. -
ArticleJuly 24, 2024Researchers are closing in on a mouse model for late-onset Alzheimer’s research
Mice don’t get Alzheimer’s—and while that’s good news for mice, it’s a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that’s genetically susceptible to late-onset Alzheimer’s, with potentially transformative implications for dementia research.