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Retinal degeneration 7 rd7

Retinal degeneration 7 (rd7)

Light microscopy shows retinal waves, whorls and rosettes that increase and decrease concordant with retinal spots and later on-set photoreceptor degeneration. A 380-nt deletion from the coding region of a photoreceptor-specific nuclear receptor gene,Pnr, causes retinal abnormalities in rd7 mice.

Gene

Mouse Chromosome

Human Chromosome

Retinal ONL disappear by

Strains

rd7

9

15q23

30

77-2C2a-special; C57BL/6J-

rd7

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