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APOE Models

MODEL	JAX #	TYPE	DESCRIPTION	SOURCE	NOMENCLATURE	REFERENCE
APOE2	29017	Knock-in	mouse exons 2-5 and introns replaced with human APOE2 sequence	MODEL-AD	B6.Cg-Apoe^{em3(APOE*)Adiuj}/J
APOE3	29018	Knock-in	mouse exons 2-5 and introns replaced with human APOE3 sequence	MODEL-AD	B6.Cg-Apoe^{em2(APOE*)Adiuj}/J	PMID:35370604
APOE4	27894	Knock-in	mouse exons 2-5 and introns replaced with human APOE4 sequence	MODEL-AD	B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj}/J	PMID:35370604
APOE3-GR (TOMM40VL)	38623	Genome replacement	20kB human construct including entire TOMM40-S/APOE3 loci	Gottschalk	C57BL/6-Tc(HSA19*)VLDkn/J	PMID:37458041
APOE3-GR (TOMM40S)	38624	Genome replacement	20kB human construct including entire TOMM40-VL/APOE3 loci	Gottschalk	C57BL/6-Tc(HSA19*)SDkn/J	PMID:37458041
APOE3-GR	38918	Genome replacement	A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC.	Koob	B6J.B6N-Tc(HSA19*APOE_i3)1Mdk/J	PMID:38343132
APOE4-GR	38919	Genome replacement	A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC.	Koob	B6J.B6N-Tc(HSA19*APOE_i4)1Mdk/J	PMID:38343132
APOE3-Christchurch	39778	Knock-in	The Christchurch AD protective variant (R154S) was knocked in to humanized APOE3 (#29018)	Sasner	B6.Cg-Apoe^{em4(APOE*)Msasn}/J
APOE4-Christchurch	39777	Knock-in	The Christchurch AD protective variant (R154S) was knocked in to humanized APOE4 (#27894)	Sasner	B6.Cg-Apoe^{em3(APOE*4)Msasn}/J
APOE-Christchurch	39301	Knock-in	The Christchurch AD protective variant (R136S) was knocked in to the mouse APOE locus	MacGregor	C57BL/6J-Apoe^em1Aduci/J
APOE3-Jacksonville	39776	Knock-in	The Jacksonville AD protective variant (V236E) was knocked in to humanized APOE3 (#29018)	Sasner	BB6.Cg-Apoe^{em1(APOE*)Msasn}/J
APOE switch, 4s2	34676	cre-inducible human isoform swap	expresses hAPOE4; hAPOE2 expressed post-cre	Johnson	B6.129S(Cg)-Apoe^{tm1(APOE*)Ljohn}/J
APOE switch, 4s3	38051	cre-inducible human isoform swap	expresses hAPOE4; hAPOE3 expressed post-cre	Sasner	C57BL/6J-Apoe^{em8(APOE*)Msasn}/J
APOE switch, 3s4	38050	cre-inducible human isoform swap	expresses hAPOE3; hAPOE4 expressed post-cre	Sasner	C57BL/6J-Apoe^{em7(APOE*)Msasn}/J
APOE switch, 3s2	38052	cre-inducible human isoform swap	expresses hAPOE3; hAPOE2 expressed post-cre	Sasner	C57BL/6J-Apoe^{em10(APOE*)Msasn}/J
APOE reporter	39779	Knock-in	A P2A-floxed stop GFP was inserted downstream of the Apoe coding region	Sasner	C57BL/6J-Apoe^em5Msasn/J

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