| MODEL |
JAX # |
TYPE |
DESCRIPTION |
SOURCE |
NOMENCLATURE |
REFERENCE |
| APOE3-GR |
38918 |
Genome replacement |
A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E3) to APOC2 |
Koob |
B6J.B6N-Tc(HSA19*APOE_i3)1Mdk/J |
PMID:38343132
|
| APOE4-GR |
38919 |
Genome replacement |
A 30kB deletion including mouse Apoe to Apoc2 is replaced by the syntenic 47kB region from human chromosome 19 including human APOE (isoform E4) to APOC2 |
Koob |
B6J.B6N-Tc(HSA19*APOE_i4)1Mdk/J |
PMID:38343132
|
| APP-GR |
38920 |
Genome replacement |
350kB human construct replacing mouse App |
Koob |
B6J.B6N-Apptm1.1(APP)Mdk/J |
PMID:38343132
|
| MAPT(H1.0)-GR |
35398 |
Genome replacement |
190kB human construct of H1 haplotype replacing mouse Mapt |
Koob |
B6J.B6N-Tc(HSA17)2Mdk/J |
PMID:38343132
|
| MAPT(H2.1)-GR |
33668 |
Genome replacement |
190kB human construct of H2 haplotype replacing mouse Mapt |
Koob |
B6J.B6N(CBA)-Tc(HSA17)1Mdk/J |
PMID:38343132
|
| MAPT(H1.0*)P301L-GR |
37420 |
Genome replacement |
190kB human construct of H1 haplotype with P301L variant replacing mouse Mapt |
Koob |
B6J.B6N-Tc(HSA17*P301L)1Mdk/J |
PMID:38343132
|
| MAPT(H1.0*N279K)-GR |
35794 |
Genome replacement |
190kB human construct of H1 haplotype with N279K risk variant replacing mouse Mapt |
Koob |
B6J.B6N(Cg)-Tc(HSA17*N279K)1Mdk/J |
PMID:38343132
|
| MAPT 10IVS+16 C>T |
36664 |
Genome replacement |
190kB human construct of H1 haplotype with non-coding C to T (rs63751011) mutation in intron 10 replacing mouse Mapt |
Koob |
B6(Cg)-Tc(HSA17*)1Mdk/J |
PMID:38343132
|
| PSEN1-GR |
39177 |
Genome replacement |
106kB human construct replacing the mouse Psen1 locus |
Koob |
B6J.B6N-Psen1tm1.1(PSEN1)Mdk/J |
PMID:38343132
|
| SNCA-GR WT |
39166 |
Genome replacement |
158kB of the human SNCA genomic region replaces the mouse Snca locus |
Koob |
B6J.B6N-Sncatm1.1(SNCA)Mdk/J |
PMID:38343132
|
| SNCA-GR A53T |
39167 |
Genome replacement |
158kB of the human SNCA genomic region with the A53T mutation replaces the mouse Snca locus |
Koob |
B6J.B6N-Sncatm2.1(SNCA*A53T)Mdk/J |
PMID:38343132
|
| SNCA-GR E46K |
39168 |
Genome replacement |
158kB of the human SNCA-GR E46K genomic region with the E46K mutation replaces the mouse Snca locus |
Koob |
B6J.B6N-Sncatm3.1(SNCA*E46K)Mdk/J |
PMID:38343132
|
| TARDBP |
39101 |
Genome replacement |
65kB human TARDBP genomic region replacing the mouse Tardbp locus |
Koob |
B6J.B6N-Tardbptm1.1(TARDBP)Mdk/J |
PMID:38343132
|