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Late-onset AD base models

MODEL	JAX #	TYPE	DESCRIPTION	NOMENCLATURE	REFERENCE
LOAD1 = APOE4/Trem2*R47H	28709	compound KI	APOE4 & Trem2^R47H KI	B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J	PMID:34707490
LOAD2 = Abeta/APOE4/Trem2*R47H	30670	compound KI	Humanized Aβ1-42, APOE4 & Trem2^R47H KI	B6.Cg-Apoe^{tm1.1(APOE*4)Adiuj} App^em1Adiuj Trem2^em1Adiuj/J	PMID:38735056
LOAD3 = Abeta/APOE4/MAPT(H1.0)	37778	compound KI	Humanized Aβ1-42, APOE4 & humanized TAU of H1 haplotype	B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Tc(HSA17)2Mdk App^em1Adiuj/J
Abeta/APOE4	34415	compound KI	Humanized Aβ1-42 & APOE4	B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj}App^em1Adiuj/J
Abeta/APOE3	34455	compound KI	Humanized Aβ1-42 & APOE3	B6(SJL)-Apoe^{em2(APOE*)Adiuj}App^em1Adiuj/J
Abeta/MAPT(H1.0)	38908	compound KI	Humanized Aβ1-42 & humanized TAU of H1 haplotype	B6.Cg-Tc(HSA17)2Mdk App^em1Adiuj/J
MAD1	38104	compound KI	Humanized floxed Aβ1-42, APOE4 & humanized TAU of H2.1 haplotype	B6.(Cg)-Apoe^{tm1.1(APOE*4)Adiuj}Tc(HSA17)1Mdk App^tm1.1Aduci/AduciJ
MAD2	38105	compound KI	Humanized floxed Aβ1-42 with Swedish and Iberian mutations, APOE4 & humanized TAU of H2.1 haplotype	B6.(Cg)-Apoe^{tm1.1(APOE*4)Adiuj}Tc(HSA17)1Mdk App^em2Aduci/AduciJ

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Late-onset AD base models