About Us

I have a strong background in oncology where I have extensively worked with human tumor samples and primary cells to characterize and identify new treatment vulnerabilities. In my current role, I am using diverse tools like spatial transcriptomics, In situ sequencing and spatial epigenomics to characterize an array of tissue types from normal and diseased states.

I am responsible for organizing, coordinating, executing and interpreting single cell transcriptomic and epigenomic experiments from tissue to data.  I act as the on-site head of single cell laboratory in Bar Harbor and report to Farmington-based Associate Director. I communicate directly with faculty and associated research staff in the design and execution of experiments.  I supervise one direct report currently and look forward to expanding as new single cell technologies are developed.

A former physicist turned molecular and cellular biology core facility leader, I lead a multi-disciplinary team of scientists and bioinformaticians that leverages single cell and spatial 'omics technologies to interrogate molecular phenotypes of cells in isolation, in tissue, and in vitro using cutting-edge technologies. I am passionate about data analysis & visualization, high performance computing, and understanding emergent phenomena at single cell resolution.

Bill Flynn on Google Scholar

Responsible for customer sample preparation submitted for droplet-based and spatial transcriptomic single cell assays using 10x Genomics platforms; continue down-stream protocols leading to high quality NGS libraries for sequencing. Design and execute RND experiments to improve existing workflows within the lab; innovate on manufacturer protocols to refine experimental design and optimize throughput. Perform novel single cell methods, working alongside research scientists, to expand lab expertise and explore possibilities within the progressing single cell field.

Grace Frohock on Orcid

I started working at JAX in 2018 at Dr. Williams lab, where I worked for 4 years. Our research goals were to define the role of Tfh13 cells in eliciting anaphylactic IgE to allergens and identify specific molecular targets that could be leveraged diagnostically and therapeutically for allergies. I have also studied WFDC21P, a long non-conding RNA highly expressed in human bronchial epithelial cells and its role in asthma.

In the beginning of 2022, I joined the Single Cell Biology lab and since then have been applying and developing my skills in molecular biology. I perform specialized single cell and spatial multiomics experiments, while focusing on obtaining high quality results for our customers and on my communication with them, explaining our services and methods. I am also a good team player that likes to help, teach, and learn from my colleagues.

         Jessica Grassman on Orcid          

Jessica Grassman on Google Scholar

I have 6 years of experience in clinical histology labs preparing microscopic slides for diagnostic evaluation by pathologists. This work included receiving, processing, cutting and staining a variety of human tissues and performing special stains and IHC after H&E analysis. I earned my master's degree in molecular biology from CCSU in August 2024. My thesis focused on using a complementation strategy between castaneous mice carrying the Bolt mutation and Axin2tm1Yaz mice (ordered from JAX!) to determine the location of the Bolt mutation. I anticipate serving as a co-author in a publication describing the collective work of Dr. Thomas King's lab on the Bolt mutation at CCSU. I am excited to be a part of the SCBL team and look forward to the work I will be doing here at JAX.

Cellular biologist providing single cell services including spatial and transcriptomic analyses to research clients.
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I am a Johnson State College alumni as of May 2010 with a bachelors of science in biology with a minor in environmental science, and graduated from the University of Maine in 2023 with a Professional Science Masters with a focus in Bioinformatics. I worked with VT EPSCoR for two years preforming microbial source tracking of E. Coli and determining phosphorus pollution in tributaries of the Lamoille River. I have a keen interest in ecology, and especially microbial ecology. I am currently working as a Molecular and Call Biology Technologist at the Jackson Laboratory in Bar Harbor. Here I primarily work on custom mouse models for disease study using crispr technologies, molecular cloning, recombineering, and genotyping including PCR, sequencing, and southern blot. I am also responsible database and inventory management, and equipment monitoring and upkeep. In 2021 I transitioned to the Single Cell Biology core at the Jackson Laboratory where I work with 10x Genomics single cell and spatial analysis including standard, high throughput, ATAC, multiome, and fixed RNA. Spatial transcriptomics including visium, cytassist, and IMC. Prior to my science career I trained and worked as a carpenter and tradesman for many years. I have recently started my own business doing small renovations part time for customers where I am responsible for all aspects including quotes, scheduling, either doing the work myself, or contracting it out, and all of the financial aspects of this.

In my current role, I perform a variety of bioinformatics tasks including writing data-processing pipelines and data analysis in the single-cell space. The assays I've computationally worked with so far include sc-RNA-seq, ATAC-seq, ChiP-seq, and sc-CUT&TAG. I look forward to learning more about various biological assays and applying novel computational methods to process the resulting data!

In my Current role at JAX, I help maintain and improve our single cell bioinformatics workflows as well as develop infrastructure supporting data processing for new assays offered by the Single Cell Biology Lab. My current focus is mainly on multiplexed spatial omics image processing from theologies like Imaging Mass Cytometry and the Phenocycler system.

Martine Seignon on Orcid

As a Cellular Biologist I, I help core in providing the services related to high content screening. My primary responsibilities include operation and maintenance of automated liquid handler i.e. Hamilton Vantage and Opera Phenix High Content Screening fluorescent microscope. I am directly involved in one-on-one conversations/meetings with the customers and help them provide the best service and achieve their project goals using High Content Screening.

I am a cell biologist by training, with experience in cancer biology, stem cell biology and regenerative medicine. My primary role at JAX is implementing highly multiplexed protein based imaging assays on a variety of technology platforms. My goal is to aid JAX and UCONN researchers in integrating multiplexed imaging into their studies, from project design to data delivery and analysis. My R&D work includes developing standardized reagent resource databases, testing and establishing newly developed scientific methods and process improvements in existing Single Cell Biology service offerings.

Trained in single cell biology techniques including droplet-based assays and spatial transcriptomics. I have used antibody-based techniques (CODEX/IMC/IHC) to uncover spatial relationships of various markers at the single cell level, as well as poly-adenylated oligos or probes for uncovering RNA relationships within various tissues. SCBL primarily uses 10X Genomics to provide answers to biological questions as a service to researchers within JAX and UConn Health.