dy^W Physiological Data

Righting Reflex in dy^W

For mouse models with early-onset muscle disease and severe loss of ambulation, the open field test is not appropriate. Instead, the time for mice to right themselves after being placed on their back is measured. Wild type (WT) mice immediately right themselves, while dy^W mutants present a robust, delayed righting reflex. In this example, a test article administered for 6 weeks only mildly, and transiently improved the righting reflex.

Grip Strength

Grip strength is measured by a grip-strength meter. dy^W mice (Vehicle) are weaker than the wild type controls. Grip strength is partially restored by treating dy^W mice with a High Dose of the test compound.

Serum CK in dy^W

Serum creatine kinase (CK) is an indicator of muscle injury. dy^W mice show an increase in serum CK level (Vehicle) compared to wild type mice (WT, untreated). When treated with a test compound, dy^W mice had a dose dependent decrease in serum CK levels.