Michael Maclean
Postdoctoral Associate
I am interested in understanding how common stressors, such as obesity and diabetes, alter microglial responses and influence the development and progression of diabetic retinopathy and Alzheimer’s disease.
Neuroinflammation is typically characterized by alterations in supporting central nervous system cell types including astrocytes, myeloid, and vascular cells. In the last decade tremendous amounts of work has shed light on transcriptional responses of these cells. However, a notable gap in the literature is understanding how common stressors such obesity and diabetes influences these responses. Leveraging the Howell lab's expertise in diverse mouse models and microglia, we are characterizing how obesity and diabetes influence microglial transcriptional responses. Additionally, we are interested in how these perturbations may promote the development and progression of diabetic retinopathy and Alzheimer’s disease.
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Featured ArticleApril 25, 2024Postdocs discuss neurodegenerative conditions for 'Scientifically Speaking'
JAX’s 'Scientifically Speaking' virtual series continues May 7, featuring two postdoctoral associates taking on the challenge of neurodegenerative disease.
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Featured ArticleMarch 07, 2023Announcing the 2023 JAX Scholars
The Jackson Laboratory is proud to announce Lisa Wren, Ph.D., and Michael MacLean, Ph.D., as the 2023 JAX Scholars.